When to Choose Inclusion Body vs. Soluble Processes in Microbial Production

Are you ignoring insoluble inclusion bodies as a strategic development option?

This technical paper examines how to determine if inclusion bodies or soluble expression processes will better serve your protein when using microbial expression systems.  Our experts share decision trees and examples, and compare each step of the development and manufacturing processes for a comprehensive analysis to help you make the best choice for your drug product candidate. 

Key sections in this paper:

• Inclusion bodies as a strategic choice

• Choosing the right expression path

• Designing for refolding success

• Analytics and quality

• Scale-up, tech transfer, and manufacturability

• Commercial fit and risk