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Fermentation Manufacturing

We offer extensive development and manufacturing services using microbial expression biologics systems

Mammalian          Microbial        pDNA        Viral Vector        Cell Therapy        mRNA

CDMO Microbial Services

Our best-in-class cell line and process development services offer a comprehensive range of capabilities to meet your specific product needs.

Microbial Manufacturing and Production

We have produced 100+ products using microbial-expressed proteins and multiple modes of expression - including secretion (yeast), periplasmic secretion, soluble intracellular expression, and inclusion bodies. The AGC Biologics network has produced six commercial products using microbial systems.


Microbial Expression Systems

Our microbial services range from cell-line development and process development to clinical and commercial manufacturing. Our expertise includes experience with E. coli, Pichia pastoris with or without methanol induction​, Pseudomonas Fluorescens (PFEnex system), Bacillus (non-sporulating)​, L. casei​, and more.


Microbial Manufacturing Scales

We offer flexible manufacturing scales up to 3,000 L​ and our cell banking services meet the standards of regulatory agencies around the world. We use standard industry systems, including batch and fed-batch methods, to produce microbial drug products.


Microbial Manufacturing Track Record


Years of experience


Commercial microbial products


Microbial processes & products produced

Microbial Fermentation Development

Our capabilities include methanol feeding, oxygen enrichment, continuous centrifugation, and high-pressure homogenization capabilities, ensuring the highest quality and efficiency throughout the manufacturing process. Our cGMP-compliant systems utilize stainless steel fermenters at various scales. Whether you require small-scale production or large-scale manufacturing, our facilities are tailored to deliver optimal results for your microbial-based products.


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Large-scale fermenter bioreactor for microbial manufacturing.

Microbial Development from Clinical to Commercial


Cell Line Development

Focused on the industry’s most popular microbial expression platforms.


E. Coli and P. Pastoris

The ability to optimize media feeds and standard processes for high cell density E. coli and P. pastoris production.


Process Development

Enhanced upstream process, reliable chromatography for purification, endotoxin and host cell protein removal, and high cell density fermentation.


Analytical Development

Established robust in-house analytical methods utilizing state-of-the-art techniques to guarantee accurate and reliable characterization.

fact sheet process development - download graphic

Process Development Fact Sheet

Our extensive experience enables us to replicate existing processes or develop a customized approach, depending on your needs.

View Fact Sheet


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Locations Offering Microbial Services

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