Propelling Your Downstream Purification

Improving processes and speeding up timelines

It's simple. Improve your downstream purification productivity of the Protein A step using GORE's technology, and leverage world-class development, analytical and quality control services from AGC Biologics. 

The power of Protein A: The new age of personalized medicine often means smaller batches with higher potency and lower doses. Traditional protein A resin tends to be oversized and underutilized leading to a larger manufacturing footprint, waste, and a more complex process incurring higher costs for clinical bioprocessing and GMP manufacturing.  GORE technology, reduces complexity and risk and has been demonstrated to boost productivity 6-10x over resin, to simplify one of the most expensive and critical steps in your clinical journey.  

Gore’s pre-packed columns use a unique membrane that offers high
dynamic binding capacity at a short residence time. Designed to increase the
efficiency of protein A column purification processes, the Devices accommodate rapid cycle capability at low pressure drop. GORE Protein Capture Device consistently scale from 1mL to 1-L without compromising binding capacity, speed, or elution width (volume).  While demonstrating the ability to withstand multiple cleaning cycles, these Devices can be used as single-use, eliminating the risk associated with storing resin.

The promise of single-use manufacturing technology: AGC Biologics is able to offer increased flexibility and lower clinical and commercial manufacturing costs for customers via a single-use technology platform process. This also comes backed by a strong supply chain and decades of regulatory expertise. 

With both, you can achieve your continuous bioprocessing productivity goals, at the best manufacturing yields possible, while staying within a well-characterized and validated batch process.   

Using GORE and AGC Biologics, you will revel in consistent scale-up performance rivaling resin-based systems without the complexity and expense of new equipment or re-engineering.