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Downstream strategies for concentration and purification of Lentiviral Vectors from suspension cell-based systems


Lentiviral vectors (LVV), produced with transient quadri-transfection in 293T cell line, are extensively used for genetic modification in gene therapy, and have already shown great promise, with several clinical trials demonstrating their efficacy in treating diseases. The demand for LVV is constantly rising to support advanced clinical phases and commercial applications. In this scientific poster, presented at Advanced Therapies Week 2024, we offer an overview of the different strategies that can be used to successfully create a downstream process for the concentration and purification of lentiviral vectors from suspension cell-based systems.

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